摘要
目的:评价盐酸丁螺环酮治疗脑卒中后情感障碍及其对神经功能的影响。方法:收集2001-05/2002-06石河子大学医学院第一附属院神经内科收治的脑卒中并焦虑、抑郁患者72例,随机分为治疗组(加用盐酸丁螺环酮)和对照组各36例,治疗并观察4周。于治疗前,治疗2周末,4周末进行汉密顿焦虑量表、汉密顿抑郁量表,美国心脏病协会卒中结局量表测定,并观察盐酸丁螺环酮的不良反应。结果:治疗组治疗后2周汉密顿焦虑量表[(14.3±4.6)分],汉密顿抑郁量表[(16.5±3.3)分]分值较治疗前[(22.7±5.2),(24.6±4.7)分]下降(P<0.05),4周(汉密顿焦虑量表:6.5±3.1,汉密顿抑郁量表:8.3±2.8)下降明显(P<0.01),随焦虑、抑郁的改善,神经功能也于4周末明显改善(P<0.05)结论:盐酸丁螺环酮治疗脑卒中后焦虑、抑郁有效,且能改善患者的预后,起效较快。
AIM:To evaluate the effects of buspirone hydrochloride on post stroke affective disorder and neural function.METHODS:Seventy two patients with post stroke anxiety and depression admitted in the Department of Neurology,First Affiliated Hospital of Medical College,Shihezi University between May 2001 and June 2002,were randomly divided into treatment group(buspirone hydrochloride) and control group,36 cases for each group.They were treated and followed up for 4 weeks,and were evaluated with Hamilton Anxity scale(HAMA),Hamilton Depression Scale(HAMD),and American Heart Stroke Outcome Classification(AHA.SOC) before treatment and 2 weeks,4 weeks after treatment.The side effects of buspirone hydrochloride tablet were observed.RESULTS:The scores of HAMD(14.3±4.6) and HAMA(16.5±3.3) were decreased in treatment group 2 weeks after treatment(P< 0.05), as compared with those before treatment(22.7±5.2,24.6±4.7).The scores were decreased obviously 4 weeks after treatment(6.5±3.1,8.3±2.8,P< 0.01),and with the improvement in the severity of anxiety and depression,the neural function were obviously improved significantly (P< 0.01). CONCLUSION:Buspirone hydrochloride tablet is effective in treating anxiety and depression,and can also improve the prognosis in patients with stroke.It has the advantages of faster effect.
出处
《中国临床康复》
CSCD
北大核心
2005年第12期8-9,共2页
Chinese Journal of Clinical Rehabilitation
