摘要
目的 观察睾酮补充治疗对中年男子雄激素部分缺乏症的疗效。 方法 2001年12月至2004年4月男科门诊经雄激素部分缺乏问卷评分、血清总睾酮(TT)和游离睾酮(fT)测定筛选出雄激素部分缺乏症患者179例,平均年龄41. 8岁,无器质性疾病和病原体感染。136例作为治疗组予口服十一酸睾酮3个月, 80mg/次,每日早餐、晚餐时各1次, 43例作为对照组未予特殊治疗。观察比较治疗前后雄激素部分缺乏评分和性激素的变化。 结果 治疗组治疗后1、3个月雄激素部分缺乏评分总分和构成评分与治疗前比较明显改善(P均<0. 01 )。治疗前患者TT、fT、雌二醇分别为(11. 9±0. 9)nmol/L、(40. 6±11. 8)pmol/L、( 128. 1±40. 1 )pmol/L。治疗后3个月分别为( 19. 1±1. 2)nmol/L, (75. 2±17. 0)pmol/L, (100. 6±27. 5)pmol/L,差异均有统计学意义(P均<0. 01 )。对照组雄激素部分缺乏评分总分和构成评分及性激素水平无显著变化。 结论 中年男子雄激素部分缺乏症在临床上客观存在,睾酮补充治疗对中年雄激素部分缺乏症安全、有效。
Objective To evaluate the efficacy of testosterone supplementation for partial androgen deficiency in middle-aged men. Methods This prospective,double-blind,placebo-controlled,randomized clinical trial was conducted in our hospital.A total of 179 patients (mean age,41.8 years) were randomly divided into study group (n=136) and control group (n=43).The 136 patients in study group received andriol (80 mg,twice a day) for 3 months;while the 43 patients in control group received no special treatment.The changes of partial androgen deficiency in aging male (PADAM) scores,serum total testosterone (TT),free-T (fT) and relevant sexual hormone levels were assessed before and after treatment. Results In study group the PADAM scores at 1 and 3 months after treatment were significantly improved compare with those before treatment (P<0.01).Before treatment and 3 months after treatment, the changes of relevant hormones [TT from (11.9±0.9)nmol/L to (19.1±1.2)nmol/L, fT from (40.6±11.8)pmol/L to ( 75.2±17.0)pmol/L,E2 from (128.1±40.1)pmol/L to (100.6±27.5)pmol/L] also revealed that patients in study group were significantly improved after treatment (P<0.01). There were no significant changes of PADAM scores and relevant hormone levels in control group (P>0.05). Conclusions Partial androgen deficiency in middle-aged men is clinically exist and testosterone supplementation for this condition is safe and effective.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2005年第4期277-279,共3页
Chinese Journal of Urology
