摘要
目的 探讨冷冻肝切除对降低肝癌术后复发率和提高生存率的价值。方法 对84例原发性肝癌行冷冻肝切除,即对可切除肝癌,先用液氮( -196℃)冷冻,将癌块冷冻成冰球然后立即作常规根治性肝切除。术后定期随访。复发率和生存率用寿命表法统计。结果 术后恢复均顺利,无手术死亡,无严重并发症。冷冻肝切除后1、3、5年生存率分别为98 .7%、83 .9%和64 .0%。术后复发率分别为15. 1%、30 .1%和39. 0%。结论 冷冻肝切除是安全可行的,有可能降低肝癌术后复发率和提高生存率。冷冻肝切除与常规肝切除的远期疗效比较,尚需进一步观察。
Objective To determine whether cryohepatectomy is potentially beneficial in reducing the recurrence and prolonging survival for hepatocellular carcinoma (HCC). Methods The study included 84 patients who underwent cryohepatectomy, cryosurgery with liquid nitrogen (-196℃) followed by the resection of the frozen tumor by conventional technique, for HCC and were closely follow-up after surgery. Recurrence and survival rates were calculated by the life- table method. Results The postoperative course of cryohepatectomy in all of the 84 patients was uneventful, there being no operative mortality or severe complications. The 1-, 3-, and 5-year survival rates after cryohepatectomy were 98.7%, 83.9% and 64.0%, respectively. The 1-, 3-, and 5-year recurrence rates after cryohepatectomy were 15.1%, 30.1% and 39.0%, respectively. Conclusions Cryohepatectomy for HCC is a safe procedure and may be potentially beneficial in reducing recurrence and prolonging survival. More time is needed to further define whether this procedure will improve long-term survival as compared with conventional resection.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2005年第7期439-441,共3页
Chinese Journal of Surgery
基金
国家"九五"医学科技攻关基金资助(96 906 01 15)
关键词
冷冻肝切除
肝癌
术后
复发
液氮
Carcinoma, hepatocellular
Cryosurgery
Hepatectomy
