摘要
目的:海狗油ω-3多不饱和脂肪酸(Sealoilω-3PUFA)具有降糖作用,本文用胰岛素抵抗型糖尿病大鼠模型从体内研究它的降血糖和增加胰岛素敏感性的作用,为临床试验提供实验依据。方法:用高脂饲料链脲霉素建立的胰岛素抵抗型糖尿病大鼠的模型灌胃给予不同剂量的海狗油ω3多不饱和脂肪酸,给药6周后,采血,收集血清,测定血脂四项、血糖值、胰岛素值及肝糖原。结果:海狗油ω3多不饱和脂肪酸4 .8、2 .4、1.2g·kg-1可使升高的血清甘油三脂分别降低4 4.1%、4 3.5 %和6 .5 % ;可使降低的血清高密度脂蛋白分别升高2 2 .4 %、8.0 %和6 .3% ;并能使升高的血清低密度脂蛋白分别下降2 7.9%、2 3.6 %和- 4.6 % ;可使血糖值既明显低于给药前31.6 %、13.3% ,- 10 .2 % ,也明显低于对照组,比对照组分别降低4 7.3% ,39.2 %和12 .2 % ,说明其降糖作用非常明显。而胰岛素分泌并不明显,分别是2 1%、- 0 .8%和15 .5 % ;海狗油ω3多不饱和脂肪酸可增强机体对胰岛素的敏感性,敏感指数分别增加12 9.5 %、6 0 .3%、5 5 .5 % ,也可降低机体对胰岛素的抵抗,抵抗指数分别降低36 .4 %、39 .2 %和0 .9%。海狗油ω3多不饱和脂肪酸4 .8、2 .4、1.2g·kg-1能加强肝糖原的合成,分别增加4 1.8%、2 9.8%和- 16 .2 %。结论:海狗油ω-
AIM: To investigate the effects of seal oil ω-3 polyunsaturated fatty acids (ω-3 PUFA) on blood glucose research in insulin resistance diabetes rats. METHODS: Different dosage the seal oil ω-3 PUFA were administered to the insulin resistance diabetes rats model caused by the high fat feed chain streptozotocin. After administration for 6 weeks, the blood fats four items, blood sugar value, insulin value and liver glycogen were determined. RESULTS: The seal oil ω-3PUFA 4.8, 2.4, and 1.2 g·kg -1 reduced the serum triglyceride levels by 44.1%, 43.5% and 6.5%, respectively, increased the serum HDL-cholesterol levels by 22.4%, 8.0% and 6.3%, respectively, and decreased the blood serum LDL-cholesterol levels by 27.9%, 23.6% and - 4.6%, respectively. The blood sugar value obviously decreased before the medicine by 31.6%, 13.3%, - 10.2%, respectively. But the insulin secretion was not decreased. The seal oil ω-3PUFA strengthened the sensitivity of organism to the insulin, and the sensitive index increased by 129.5%, 60.3%, 55.5%, respectively. CONCLUTION: The ω-3PUFA can effectively improve the insulin resistance syndrome caused by high glycerin trinitrate lipemia, and the mechanisms of it falls the sugar may be related to its enhancing the sensitivity of the organism to the insulin.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2005年第3期321-325,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
