摘要
目的探讨人类免疫缺陷病毒(HIV)和丙型肝炎病毒(HCV)共感染患者发展到肝硬化的情况及原因。方法将观察对象分为HIV和HCV共感染组、单独HCV感染组。回顾性比较HIV和HCV共感染患者、单独HCV感染患者15年内发展到肝硬化的情况。结果HIV和HCV共感染患者15年内肝硬化发生率为16.4％(23／140)明显高于单独HCV感染组3.0％(1／33),差异有统计学意义,x2=4.012,P=0.045。CD4+、CD8+T淋巴细胞计数在HIV和HCV共感染组分别为(200.0±134.1)个／μl及(880.6±444.2)个／μl,而单独HCV感染组分别为(752.3±251.7)个／μl及(529.0±170.7)个／μl,两组比较差异有统计学意义,t值分别为12.020和7.600,P值均<0.01;HCVRNA(+)、抗HCV(+)数与HCVRNA(+)、抗-HCV(-)数,在HIV和HCV共感染组为89例和15例,在HCV感染组为25例和0例,两组间差异有统计学意义,x2=4.080,P=0.043。结论HIV和HCV共感染可加速肝硬化的进展,可能与HIV对机体的细胞免疫、体液免疫有关。
Objective To study the progression of cirrhosis in patients with HIV/HCV coinfection. Methods The patients were divided into two groups, HIV/HCV coinfection group (n=140) and simple HCV infection group (n= 33). A retrospective study was designed to compare the development of cirrhosis in a 15-year period between the two groups. Results The development of cirrhosis in the HIV/HCV coinfection group was higher than that in the simple HCV infection group (16.4% vs 3.0%, P=0.045). Counts of CD4+ T and CD8+ T in the HIV/HCV group were 200.0±134.1 cells/μl and 880.6±444.2 cells/μl, respectively. The counts of CD4+ T and CD8+ T in the group of simple HCV infection were 752.3±251.7 cells/μl and 529.0±170.7cells/μl, respectively. There were significant differences between the two groups regarding the counts of CD4+ T and CD8+ T (P<0.01). Comparing the cases of HCV RNA (+) and anti-HCV (+) with the cases of HCV RNA (+) and anti-HCV (-), we found that the ratio was 89 to 15 in the group of HIV/ HCV coinfection, and 25 to 0 in the group of simple HCV infection. The difference between the two groups was statistically significant (P=0.043). Conclusion HIV/HCV coinfection can accelerate the progression of cirrhosis, which may be due to the effect of HIV on cellular immunity and humoral immunity.
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2005年第4期264-266,共3页
Chinese Journal of Hepatology
基金
首都医科大学基础与临床课题(03JL10)国家 "十五"科技攻关项目(2001BA705801)卫生部科技处资助项 目(WA2002-01-01)
