摘要
目的 研究血清前列腺特异性抗原 (Prostatespecificantigen ,PSA)、游离前列腺抗原 (Freeprostatespecificantigen ,F PSA)与总前列腺抗原 (Totalprostatespecificantigen ,T PSA)之比值 (F/T)对前列腺肿瘤 (Prostatecancer ,PCa)的诊断价值和阳性预警值。方法 应用化学发光法检测健康对照组 6 0例 ,前列腺增生 (Benignprostatehyperplasia ,BPH) 78例 ,慢性前列腺炎(Chronicprostateinflammatory ,CPI) 80例和PCa患者 5 3例的血清T PSA、F PSA含量并计算其F/T值和对各组的检测结果进行比较分析。结果 PCa组的T PSA均值明显高于其他 3组、其F/T值明显低于其他 3组 (P <0 .0 1 ) ;BPH组、CPI组和健康对照组间F/T值无差异 (P >0 .0 5 ) ;BPH组与CPI组间T PSA无差异 (P >0 .0 5 ) ,但高于健康对照组 (P <0 .0 1 )。当T PSA在 4 .0～ 1 0 .0ng/ml时 ,3组研究对象间的T PSA值无差异 (P >0 .0 5 )。以T PSA≥ 4 .0ng/ml和T PSA≥ 30 .0ng/ml为界区分前列腺良恶性疾病 ,PCa诊断敏感性分别为 1 0 0 %、4 7.2 %,特异性分别为 35 .3%、1 0 0 .0 %;当F/T≤ 0 .2 0和F/T≤ 0 .1 5时 ,PCa诊断敏感性分别为 96 .2 %、90 .6 %,特异性分别为 4 3.6 %、6 2 .3%。结论 T PSA结合F/T可提高PCa的诊断能力 ,当T
Objective To evaluate serum total prostate specific antigen (T-PSA) and free prostate specific antigen (F-PSA) ratio F-PSA/ T-PSA ( F/T) for diagnosis of prostate cancer and its positive alarm value.Methods Serum F-PSA and T-PSA were determined in 53 patients with prostate cancer (PCa),80 with chronic prostatitis (CP),78 with benign prostatic hyperplasia (BPH),and 60 healthy subjects by using chemiluminescent assay,and the ratio of F-PSA /T-PSA (F/T) was calculated.Data obtained from these 4 groups were compared and analyzed.Results T-PSA and F/T ratio in PCa group were significantly higher and lower,respectively,than those in the other 3 groups (P< 0.01) .There were no significant differences in F/T ratio between BPH group,CPI group and healthy control group (P>0.05).T-PSA showed no significant difference between BPH group and CPI group (P>0.05) ,meanwhile,T-PSA in these two groups was significantly higher than that in control group (P<0.01). There were no significant differences between the three groups (P>0.05) when T-PSA was between 4.0 ng/ml and 10.0 ng/ml .Using T-PSA≥4.0 ng/ml or T-PSA ≥30.0 ng/ml as the criterion for distinguishing between benign and malignant PCa,its diagnostic sensitivities were 100% and 47.2% ,and specificities were 35.3% and 100%,respectively.When the cutoff value was set at F/T ≤0.20 or ≤0.15,the sensitivity was 96.2% or 90.6%,and specificity was 43.6% or 62.3%,respectioely.Conclusions Combined detection of T-PSA and F/T ratio enhances diagnostic efficiency.Patients with abnormal T-PSA and F/T≤0.20 should be followed up regularly and examined to identify PCa in time.
出处
《武警医学》
CAS
2005年第3期174-176,共3页
Medical Journal of the Chinese People's Armed Police Force
