摘要
利用免疫组化和酶联组化法,对38例结肠直肠癌和5例肠炎和腺瘤组织,进行P53、ER和PR检测,以便观察上述标记物的阳性率和它们之间的相关性。结果表明,结肠炎者阴性,在结肠癌和直肠癌中阳性率分别为44.4％和60％,ER阳性率与P53相同;PR阳性率分别为38.9％和和50％。P53和ER阳性一致率为55％;P53和PR阳性一致率为50％。本实验提示P53、ER、PR在大肠癌中的表达与年龄无明显相关性。
In order to observe positive rate and correlation of P53,PR and ER, 38 carcinomas of colon and rectum and 5 colonitis were de-terminde for using immunohistochemistry method and enzymohistochemistry. The results showed that the epithelium and intestinal gland of colonitis were both negative.In carcinomas of respectively, positive rate of P53 were 60% and 44.44% respectively, positive rate of P53 and ER were all the same, the positive of PR were 50% and 38.9% erparately, the positive identical rate between P53 and ER, P53 and ER were 55% and 50% respectively. The study indicated that between expressions of P53.ER and PR in carcinoma of large intestine and aging had not obvious correlation.
关键词
P53基因
受体
直肠肿瘤
结肠肿瘤
carcinoma of colon
carcinoma of rectum. P53 gene
receptor
