摘要
目的 预测黑色素瘤抗原MAGE-12的HLA-A2限制性CTL表位。方法 采用SYFPEITHI超基序远程预测系统与量化基序多项式法、延展基序联合应用,筛选MAGE-12抗原HLA-A0201限制性CTL表位。结果 共预测出5个MAGE-12抗原HLA-A2限制性CTL表位。结论 超基序法与量化基序,延展基序联合应用可以提高预测效率,为实验方法探索MAGE-12的表位提供有用线索。
Objective To predict the HLA-A2-restricte d CTL epitopes from melanoma antigen MAGE-12. Methods HLA- A2-restricted CTL epitope of MAGE-12 was predicted by peptide supermotif predict ion combined, quantitative motif and extended motifs. Results Five HLA-A2-restricted CTL epitope candidates derived from the tumor antig en MAGE-12 were selected. Conclusion The combination of supermotif, quantitative motif and extended motifs can improve the prediction ef ficiency. The predicted epitopes provided useful hints to probe epitopes in MAGE -12 by experiments.
出处
《现代肿瘤医学》
CAS
2005年第2期149-151,共3页
Journal of Modern Oncology
基金
国家自然科学基金资助项目(30271464)
