摘要
研究表明，金丝桃甙（ＨｙＰ）对兔乳头肌模型，与维拉帕米（Ｖｅｒ）一样，呈剂量依赖性抑制ＣａＣｌ２诱发的正性肌力作用，使ＣａＣｌ２的量－效曲线显著右下移动，但不平行，可能系非竞争性拮抗；对豚鼠心室肌动作电位模型，Ｈｙｐ可显著缩短动作电位二相平台期，而对膜静息电位、动作电位零相上升幅度和速率及动作电位时程无明显影响；在小鼠心房组织标本上，Ｈｙｐ和Ｖｅｒ一样，可抑制高钾诱发的４５Ｃａ内流。上述结果提示Ｈｙｐ对钙内流有一定阻滞作用。
Hyperin(Hyp)was shown to inhibit the positive inotropic action of
calcium ion onthe isolated papillary muscles and shift the dose
response curve of calcium ion to the right.As a plotlg(x一1)us一
lg(B)resulted in straight lines with slopes of一0.625.On the action
potentials ofguinea pig myocardical cells,Hyp markedly decreased the
duration of plateau of action potentials(APD20%)but did not influence
the APD100%, RP,APA,OS and Vmax.In the atrium preparationsof mice,
Hyp significantly inhibited influx of45Cainduced by high K+,All
findings indicate that Hypcan inhibit the in ward flow of calcium
ion.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第1期15-19,共5页
Acta Pharmaceutica Sinica
关键词
金丝桃甙
钙离子内流
动作电位
Hyperin
Inward flow of calcium ion
Action potentials
