摘要
目的 观察支气管上皮增生性病变的病理形态特点 ,为肺癌癌前病变的早期诊断和分子生物学研究提供依据。方法 收集 36 0例手术切除的肺鳞状细胞癌和肺炎性病变大体标本 ,HE染色 ,显微镜下寻找和观察支气管上皮各种增生病变。结果 描述了支气管上皮轻度、中度、重度和原位癌的病理形态特点。结论 依据WHO的分类标准 ,有纤毛上皮的非典型增生病变占所有癌前病变的 5 4 4 % (80 14 7)。建议忽略覆盖在非典型增生病变之上的支气管纤毛柱状上皮 ,仅考虑非典型增生病变 ,将细胞异型程度视为重要的诊断指标 ,化生的鳞状上皮程度和上皮层厚度作为次要因素 。
Objective To observe morphological aspects of pulmonary squamous dysplasia and to provide objective criteria for early clinical diagnosis as well as genetic studies. Methods A total of 360 lung resection specimens from patients with lung cancer and pulmonary inflammatory lesions were collected. By HE staining, preinvasive bronchial lesions in those specimens were observed microscopically. Results Morphological aspects of various hyperplastic lesions occurring in the bronchia were described. Conclusion WHO criteria for assessing dysplasia assume a full thickness squamous epithelium. It is difficult to grade dysplasia in this partially transformed epithelium which accounts for 54.4% (80/147). It is recommended to ignore the overlying respiratory epithelium and epithelial thickening, but to emphasize cytological aberration in attemping to grade the squamous layer as only a “low' or “high' grade.
出处
《诊断病理学杂志》
CSCD
2004年第5期320-322,I084,共4页
Chinese Journal of Diagnostic Pathology
