摘要
目的研究血小板活化因子(PAF)与年龄及其动脉粥样硬化性脑梗死的关系.方法研究对象分别来自保健科健康普查、体检普通人群和脑梗死住院病人.采用放射免疫法检测普通人群不同年龄段组(20～29,30～39,40～49,50～59,60～69,70～79岁共6组),和动脉粥样硬化性脑梗死组(60～69岁)的血浆PAF水平.结果普通人群随着年龄的增加,血浆PAF水平呈现增高趋势,与年龄呈显著正相关(r = 0.3348,P< 0.01);在40～49岁年龄段组血浆PAF水平(388 ± 128)pg/ml已显著高于20～29年龄段组(338 ± 96)pg/ml,P= 0.034.动脉粥样硬化性脑梗死组血浆PAF值显著高于普通人群60～69同年龄段组[(504 ± 108)pg/ml vs (433 ± 103)pg/ml,P= 0.007].结论血PAF水平随年龄增加而升高,高血PAF可能是动脉粥样硬化性脑梗死的危险因素之一.
Objective To explore the relationship between the levels of plasma platelet-activating factor and aging and atherosclerotic cerebral infarction. Methods The subjects were from the health mass investigation, physical examination population and cerebral infarction inpatients in healthcare department. Plasma PAF levels of different age groups (21~30, 31~40, 41~50, 51~60, 61~70, 71~80 years old, 6 groups) and atherosclerotic cerebral infarction group were determined by radioimmunoassay. Results With the aging, plasma PAF levels showed increasing trend, which had positive relationship to age (r= 0.334 8, P< 0.01). Plasma PAF levels in 41~50 years old group 〔(388± 128)pg/ml〕 were significantly higher than that (338± 96)pg/ml in 21~30 years old group (P=0.034). Plasma PAF concentrations in atherosclerotic cerebral infarction group were significantly higher than that in 61~70 years old group 〔(504 ± 108)pg/ml vs (433 ± 103)pg/ml, P=0.007〕. Conclusions With aging, plasma PAF increased. High plasma PAF could be one of risk factors of atherosclerotic cerebral infarction.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2005年第3期242-244,共3页
Chinese Journal of Gerontology
基金
深圳市科技基金资助项目(200204137)
关键词
血小板活化因子
增龄
脑梗死
动脉粥样硬化
Platelet-activating factor
Aging
Cerebral infarction
Arteriosclerosis
