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多形核白细胞凋亡在全身炎症反应综合征中的作用 被引量:1

Role of PMNs Apoptosis in SIRS
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摘要 全身炎症反应综合征被认为是多器官功能障碍综合征的前奏 ,许多炎症细胞参与了这一过程 ,释放各种炎症介质与细胞因子 ,引起炎症失控和免疫紊乱。多形核白细胞 (PMNs)是人体对抗感染与异己物质的第一道防线 ,通常情况下PMNs以凋亡的形式被清除 ,对周围组织无损伤 ,但是在全身炎症反应综合征中 ,PMNs的凋亡明显延迟 ,其细胞毒性的持续存在造成炎症反应过度 ,在其坏死时细胞膜破裂 ,各种细胞毒性物质被释放 ,进一步造成组织器官损伤。许多炎症介质和细胞因子参与了PMNs凋亡的调控 ,关于凋亡调控机制的研究也在进一步深入。
出处 《国外医学(儿科学分册)》 2005年第2期71-73,共3页 Foreign Medical Sciences(Section of Pediatrics)
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