摘要
研究目的探索具有抗癌活性的萜类化合物的合成方法。方法选择类似结构单元的化合物，采用事先引入所需官能团，利用硫稳定的负碳离子与卤代径亲核取代反应将片断偶联为所需化合物．结果以香叶醇为起始原料，经过4步反应合成出一种新的化合物．结论此合成路线方法简便且收率高，为天然萜类化合物合成提供了行之有效的方法。
Objective To search the synthesis on the terpenoids which shown antitumor activity.Method Using the simple compound as the starting material, the coupling reaction was accomplished by the SN reaction of sulfurstabilized carbonion with chlorated compound.Results A new compound has been synthesized from Geraniol through four steps.Conclusion This synthetic route is short with a high yield, and provided a method for synthesis of natural terpenoid.
出处
《新乡医学院学报》
CAS
1994年第2期175-177,共3页
Journal of Xinxiang Medical University
关键词
萜类化合物
合成
药物化学
terpenoids
antitumor activity
synthesis
