摘要
采用动态光散射、ζ电势等方法研究了季铵盐二聚表面活性剂(C12-8-C12?2Br)和十二烷基三甲基溴化铵(DTAB)在卵磷脂囊泡中的增溶作用.C12-8-C12?2Br使囊泡粒径增大,促进脂双层向胶团的转变,过程明显分为三个阶段;而DTAB与囊泡的作用则相对缓和,72h内未见明显变化.此外,用亲水头基总体积的大小,讨论了这两种表面活性剂在脂质体中的吸附行为,并对实验现象加以解释说明.
The solubilization process of quaternary ammonium surfactants within lecithin vesicles has been studied by means of optical density monitoring, dynamic light scattering (DLS) and zeta-potential. To C-12-8-C(12)center dot 2Br-liposome system, the vesicle-to-micelle structure transition occurred within 6 h, and could be described by a simple three-stage model. While the DTAB-liposome system remained vesicle state even after 48 h. The size of total volume of hydrophilic head group (V-head) as the main influencing factor was investigated.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2005年第6期450-454,F005,共6页
Acta Chimica Sinica
基金
国家自然科学基金(No.29973033)资助项目.
关键词
表面活性剂
季铵盐
胶团
囊泡
二聚
溴化
十二烷
电势
烷基
相互作用
quaternary ammonium surfactant
liposome
solubilization process
dynamic light scattering
zeta-potential
