摘要
测定了２４例卵巢癌标本的ＤＮＡ水平、Ｓ期比例（ＳＰＦ）及雌、孕激素受体（ＥＲ、ＰＲ），分析了它们之间以及与临床病理组织学之间的关系。结果表明，卵巢癌ＤＮＡ水平、ＳＰＦ与有无腹水及病理分级有明显的关系；二倍体组的ＰＲ阳性率明显高于异倍体组；二倍体组的ＳＰＦ明显低于异倍体组；ＥＲ（－）ＰＲ（－）组的ＳＰＦ明显高于ＥＲ（＋）ＰＲ（＋）组。提示卵巢癌ＤＮＡ水平和ＳＰＦ可作为一个相对独立的反映卵巢癌生物学行为的客观指标，对估计卵巢癌的预后和选择治疗方案有较大的价值。
Tumor specimens from 24 patients with ovarian carcinoma were analyzed for DNA ploidy level,S-phase fraction (SPF), estrogen receptor (ER) and progesterone receptor (PR) .The relationships of DNA ploidy level and SPF with age,clinical stage, ascites, histologic type, pathologic grade, lymphocyte infiltration and psammoma bodies were analyzed and the relation with ER and PR was also discussed. The results showed that the relationships of DNA ploidy level and SPF with ascites and pathological grade were significant.There was no significant association between ER status and DNA ploidy level, but 75% dipliody tumors were PR+in contrast to 31% aneuploidy tumor. Receptor negative tuniors had a median S-phase of 18.85 which was significantly higher than the median S-phase of 12.82 in ER +PR + tumors.The authors consider that DNA ploidy level and SPF of ovarian carcinoma can serve as a relatively independent objective index which reflects tumors biological behaviours, and will be of great auxiliary value to prognostic factors analysis and therapy of ovarian carcinoma.
出处
《现代妇产科进展》
CSCD
1994年第3期211-214,共4页
Progress in Obstetrics and Gynecology
关键词
卵巢肿瘤
S期比例
雌激素
受体
DNA
Ovarian neoplasms
DNA
S-phase fraction (SPF)
Receptor, estrogen
Receptor, progesterone
Pathology, clinical
