摘要
观察分析人工流产组和ＲＵ４８６药物组绒毛细胞ＳＣＥ值和有丝分裂指数（ＭＩ）各２５例，结果：人工流产组绒毛细胞ＳＣＥ值为３．１１４±０．６９４７，ＭＩ为０．９２±０．３５８８；ＲＵ４８６；ＲＵ４８６药物流产组绒毛细胞的ＳＣＥ值为３．４０２±７０±０．２９７５。经统计学分析，两组ＳＣＥ值差异不具显著意义（ｐ＞０．０５），两组ＭＩ差异具显著意义（Ｐ＜Ｏ．０５），表明ＲＵ４８６阻断蜕膜孕酮受体致使绒毛变性，从而影响其有线分裂，但无明显增高绒毛细胞ＳＣＥ值作用。
he sister chromatid exchange values and the mitotic index of the chorionic villi were ob-servedin50cases of the artificia1abortion group and the drug abortion group caused by Mifepris-tone. The results were as follows :The SCE values in the artificial and drug abortion groups were3.l14土0. 6947 and 3.402±0.6576,respectively,which had no significant difference(P>0.05).The mitotic indexes in the two groups were 0.92 ± 0. 3588 and 0. 70 ± 0.7975,respectively,which had significant difference(P<0.05 ).It suggested that Mifepristone(RU486)might blockthe progestrone receptors in decidu,resulting in the degeneration of the chorionic villi and thenaffecting its mitosis.But RU486 didn' t predominantly raise the SCE values of chorionic villi.
出处
《温州医学院学报》
CAS
1994年第2期92-94,共3页
Journal of Wenzhou Medical College
关键词
米非司酮
药物流产
绒毛
有丝分裂
RU486(Mifepristone)
chorionic villi
sister chromatid exchange
mitotic index
