摘要
目的 :研究二甲基亚砜对血小板活性和功能的影响。方法 :将60份新鲜血小板样品随机分为对照组、二甲基亚砜组和洗涤血小板组 ,除对照组外 ,其余两组均加入二甲基亚砜 ,使其终浓度为3 % ,然后对洗涤血小板组进行洗涤。3组均在室温下置于临界振荡仪中保存 ,观察各组血小板粘附率、聚集功能和低渗反应回复率的变化。结果 :二甲基亚砜组血小板粘附率、聚集功能和低渗反应回复率均较对照组和洗涤血小板组降低。结论 :二甲基亚砜具有血小板保护作用 ,且其作用具有可逆性。
OBJECTIVE:To explore the effect of dimethylsulfoxid(DMSO)on the activity and function of platelet in vitˉro.METHODS:Fresh random-donor platelet unit(n=60)were divided into3equal groups.A DMSO-free group was chosen as a control group.The other two groups included a washed platelet group and a DMSO group to which DMSO was added with a final concentration of3%.All the groups were stored on a horizontal shaker at room temperature.Changes of adherence rate,aggregating function and recovery rate from hypotonic shack of platelet were observed.RESULTS:In the DMSO group,platelet adherence rate,aggregating function,and recovery rate from hypotonic shack decreased during storage comparing with control and washed platelet groups.CONCLUSION:DMSO has a protective effect on platelet and its action is reversible.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第5期334-335,共2页
China Pharmacy
基金
陕西省科学技术研究发展计划项目 (2003K10 -G34)
关键词
二甲基亚砜
血小板
聚集功能
Dimethylsulfoxid
Platelet
Aggregating function
