摘要
氮酮(Azone)和二甲基亚砜(DMSO)是两种增加多种化合物透皮吸收的物质。本文应用流动透析室和静态透析室测定了Azone和DMSO对^(125)I—氢化可的松的透皮吸收率。结果表明40％DMSO增加了^(125)I—氢化可的松的通透率,而Azone对^(125)I—氢化可的松无促进作用。
Azone and dimethyl sulfoxide(DM SO) are two agents that can enchance the percutaneous absorption of a number of different chemicals. This report delineated percutaneous penetrability of ^(125)I-cortisol with azone and DMOS by flow-through diffusion cell and statio nary diffusion cell. The results showed that 40％ DMSO increased the penetrativity of ^(125)I-cortisol and no sign of increasing percutaneous penetrativity of ^(125)I-cortisol by azone.
出处
《铁道医学》
1989年第4期200-201,共2页
Railway Medical Journal
关键词
亚砜类
氢化可的松
药理学
azones sulfoxides hydrocortisone pharmacology, clinical
