摘要
应用放射免疫法测定189例甲状腺疾病患者血清β2微球蛋白(β2-MG),结果提示Graves病未治组血清β2-MG增高,其它组及Graves病治疗缓解组血清β2-MG变化不显著。血T3、T4分别与β2-MG呈正相关。测定血清β-2MG变化对Graves病的诊断、病情估价及判断抗甲状腺药物的疗效提供了佐证。
By the application of radioimmunoassay, the concentrations of serum β_2-microglobulin (β_2-MG) were determined in 189 cases of various kinds of thyroid patients in 6 different groups(Graves' disease before treatment, remittent Graves'disease, Hashimoto's disease, thyroid adenoma, simple goiter and nodular goiter), excluding renal, necplastic and other autoimmune diseases in advance. Their results were compared with those of 30 normal controls. The incidence rate of hyper-β_2 microglobulinemia and the increase of serum β_2-MG were very evident in the Grave' diseases before treatment group (p<0.01). In the other 5 groups, the results were nearly the same as that of the control group(p>0.05). The correlation coefficients between the values of T_3, T_4 and that of β_2-MG were calculated respectively and showed high significient differences(r=0.7864, p<0.01 and r=0.3677, p<0.01). It revealed that serum T_3 and T_4 are positively correlated with the value of β_2-MG.
In Graves' disease, the increase of serum β_2-MG is the result of increased synthesis and secretion. Thus, the serum β_2-MG can be used as evidence in the diagnosis of Graves' disease and in the evaluation of patients' condition. During the use of antithyroid drugs, dynamic observation of the changs of serum β_2-MG can reflect the degree of remission of the abnormal immunologic function, the control of patients' conditions and also the judgement of the effect of antithyroid drugs.
出处
《铁道医学》
1989年第2期65-66,共2页
Railway Medical Journal
