摘要
氮酮（Ａｚｏｎｅ）是目前应用最好的药物皮肤渗透促渗剂之一。用￣３Ｈ－Ａｚｏｎｅ作示踪剂，研究了透皮吸收后，Ａｚｏｎｅ在小鼠体内的分布、离体皮肤的渗透速率和透皮吸收后Ａｚｏｎｅ在大鼠血液中的浓度和时间的关系。实验结果表明，Ａｚｏｎｅ能迅速透过皮肤进入血液循环，分布到各脏器中。体外法（ｉｎｖｉｔｒｏ）测定表明，它的平均渗透率为１．００μｇ／ｈ·ｃｍ￣２，在８ｈ内总渗透率为０．７０％。Ａｚｏｎｅ透皮吸收后，在大鼠血液中的浓度先上升，在２ｈ时达最大；然后下降，峰值浓度为２．７０μｇ／ｍｌ，到２４ｈ时仍高达１．６μｇ／ｍｌ。由此证明Ａｚｏｎｅ在皮肤上既能迅速被吸收又有持续作用。
Azone is one of the best enhancer of cutaneous Penetration. The distribution of Azone in mice af-ter percutaneous absorption and in vitro diffusion of Azone through excised mice skins using tracer ￣3H-Azone are studied. The concentration of Azone in rat’ s blood after percutaneous absorption is studiedalso. The ￣3H-Azone is found widely distributed in lung , liver. kidney , fat , heart , brain and spleen af-ter percutaneous absorption. The total diffusion ratio of ￣3H-Azone is 0. 70 per cent in 8 h. The peakconcentration(2.7μg/ml) of Azone in rat’ s blood appears at 2 h after percutaneous absorption, but re-mains l.6μg/ml at 24 h.
出处
《同位素》
CAS
北大核心
1994年第2期113-116,共4页
Journal of Isotopes
关键词
氮酮
透皮吸收
氚
同位素示踪
azone￣3H-azone distribution percutaneous absorption
