摘要
分析天津地区1987～1990年神经管畸形的监测情况。期间共监测95283出生人次,共检出神经管畸形231例,发生率为2.42‰。在231例神经管畸形中,无脑儿106例占45.9％(内部组成比用％),脊柱裂95例占41.1％,合并其它系统畸形30例占13.0％。农村围产儿神经管畸形发生率(2.75‰)高于城市围产儿(1.77‰),女性神经管畸形发生率(3.08‰)高于男性(1.81‰),差异均有显著性(P<0.01)。在产母年龄及职业分布上,畸形发生率也有显著性差异。对致畸因素的1:1配对调查表明,母亲孕早期发烧、服用西药、严重呕吐均与神经管畸形的发生有一定关系。
During the period of 1987 1990, 95 283 live and still births on full term were monitored in 21 hospitals in Tianjin. A total of 231 cases of neural tube defects (NTD) were recorded. The incidence of NTD in Tianjin was 2.42 per 1000, among which there were 106 cases of anencephaly (45.9%), 95 cases of spina bifida (41.1%), and 30 cases of NTD complicated with deformities of other systems (13.0%). The incidence of NTD in the rural area (2.75 per 1 000) was higher than that in the urban area (1.77 per 1000) (P<0.01). A female preponderance (3.08 per 1000) over the male (1.8 per 10000) was observed. The incidences of NTD in groups based on age and occupations were different. By means of the case-control study, it was found that the NTD had a close relationship with the following factors occurring in the first trimester of the mothers pregnancy: feverish disease, the use of drugs and severe vomiting.
出处
《天津医药》
CAS
1994年第6期339-341,共3页
Tianjin Medical Journal
