摘要
用放免法测定30例非溃疡对照及29例十二指肠球溃疡患者空腹血清及胃窦粘膜胃泌素、生长抑素水平。用免疫组化法及高效液相色谱法测定上两组各20例患者胃窦粘膜G、D细胞密度及多巴胺、去甲肾上腺素浓度。发现球溃疡患者胃窦粘膜多巴胺、去甲肾上腺素含量减少,而基础胃酸及高峰胃酸分泌量和胃窦粘膜胃泌素含量增加,说明球溃疡患者胃酸分泌增加可能与胃窦粘膜去甲肾上腺素、多巴胺含量减少使D细胞不能合成及分泌足够量的生长抑素以抑制G细胞及壁细胞功能有关。
The antral gastrin concentration and gastric acid secretion in duodenal ulcer patients were significantly higher than that in non-ulcer subjects (P<0.05, P< 0.01). The antral dopainine (DA) and norepinephrine (NE) in duodenal ulcer patients were lower than that in non-ulcer subjects (P<0.01, P<0.05). In duodenal ulcer patients there was a positive correlation between antral gastrin concentration and basal acid output (r = 0.448, P<0.02). The above mentioned data suggested that the decrease of antral DA and NE content, that can stimulate p-receptor on antral D-cell, may contribute to the increase of antral gastrin concentration and gastric acid secretion output in duodenal ulcer patients.
出处
《天津医药》
CAS
1994年第6期327-329,共3页
Tianjin Medical Journal
关键词
胃酸
多巴胺
十二指肠溃疡
duodenal ulcer gastric acid G, D-cell dopamine norepinephrine
