摘要
应用免疫组化技术对50例乳腺癌进行了C-erbB-2基因(C-erbB一2)、表皮生长因子受体(EGFR)、生长抑素(SS)和雌激素受体(ER)的检测,着重观察其表达的相互关系。结果表明C-erbB-2过表达和EGFR阳性反应的乳腺癌不显示SS和ER阳性反应。SS阳性的乳腺癌,一般表现为ER阳性,而C-erbB-2和EGFR为劂性反应。C-erbB-2,EGFR阳性反应提示乳腺癌分化差,腋淋巴结转移倾向高。
Sections of 50 breast carcinomas were examined for the C-erbB-2 oncoprotein (C-erbB-2), epidermal growth factor receptor (EGFR),somatostatin(SS) and estrogen receptor (ER) using the avidin-biotin immunoperoxidase technique to investigate the relationship among the above tumor markers.The results suggested that there were positive correlation between SS and ER and negative correlation between SS and C-erbB-2, EGFR.In conclusion,the results showed that amplification of the C-erbB-2 and EGFR positive were more frequent in tumors with poor nuclear garde and with lymph mode metastasis.
出处
《天津医药》
CAS
1994年第3期155-157,共3页
Tianjin Medical Journal
关键词
乳腺癌
C-ERBB-2基因
表皮生长因子
C-erbB-2 oncoprotein epidermal growth factor receptor somat- ostinestrogen receptor breast carcinoma
