摘要
报告40例肢端肥大症患者骨质与矿物质变化。胸腰椎70％有骨质变化,47.5％的鞍背与鞍底有骨质疏松,其余均有骨肥厚。血GH、PRL、T_4、BGP,血糖与血磷,尿钙、磷、镁、HOP及尿糖平均值显著高于正常值,血钙、TSH、T_3、PTH与CT值均属正常水平,血镁与AKP值则低于正常。提示各部位骨质变化不同且与多种激素及矿物质代谢变化有关。
Changes in skeletal system and mineral metabolism in 40 cases of acromegaly were reported. The data showed that 9 cases had thoracic and lumbar vertebrae oste-opetrosfs, 8 cases had osteoporosis, and 11 cases had both osteoporosis and osteop-etrosis. All of 28 cases (70%) had lumbar vertebrae skeletal changes. There were 19 cases (47.5%) of bone density decreased at sella turcica bone. All the cases had cranial deformity recognized externally.
The data showed that mean level of serum GH PRL, T4, P, BGP, Glu, and urinary Ca, P> Mg, HOP and Glu were statistically and significantly increased than the normal level (P<0.01), but the level of serum Ts, TSH, Ca, PTH, CT were normal. The mean level of serum Mg and AKP in patients were significantly decreased than the normal level. Our findings suggested that acromegalic changes in the skeletal and mineral metabolism were most striking. The skeletal system was particularly affected, these changes were in close relationship with changes of GH and so on.
出处
《天津医药》
CAS
1994年第2期69-71,共3页
Tianjin Medical Journal
关键词
肢端肥大症
生长激素
骨肥厚
acromegaly hyperostosis GH osteoporosis osteopetrosis
