摘要
30例SLE患者伴血栓形成7例,发生率为23.3％。通过PAGT、vWF:Ag、Fn、APTT、ATⅢ:Ag、ATⅢ:C、PLG及LA、ACA的检测并复习文献,认为血管内皮损伤、狼疮抗凝物、抗心磷脂抗体、获得性抗血栓形成机制的缺陷(PC、PS、ATⅢ)及纤溶机制的改变是血栓形成的主要因素。
Thirty cases of SLE were entered in the study. Incidence of thrombogenesis was 23.3%. The following studies were done to all subjects: platelet aggregation rate (PAGT), vWF:Ag, APTT, fibronection (Fn), ATIII:Ag, ATIII:C, plasminogen(PLG) and lupus anticoagulant(LA). The anticardiolipin antibodies (ACA) were done to 11 cases. The results showed that the levels of PAGT, vWF:Ag and Fn were increased (P<0.01, 0.01, 0.05), APTT was prolonged(P<0.01), and the levels of ATIII'Ag,AT-III:C and PLG were not changed(P<0.5, 0.1, 0.2). In 2 cases of 7 cases with embolic thrombosis the levels of ATIII'C was lowered and ATIII' Ag was increased.There was the presence of the LA in 4 cases of them(13.3%), 5 cases(45.4%) were found ACA in 11 cases. We suggested that increased thrombogenesis observed in SLE was derived from multiple mechanisms, including vascular endothelial cell damage, LA, ACA, acquired deficiencies of natural anti-thrombotic mechanisms(protein C, protein S, antithrombin III), and impaired fibrinolytic mechanisms.
出处
《天津医药》
CAS
1994年第1期14-16,共3页
Tianjin Medical Journal
关键词
系统性
红斑狼疮
血栓形成
systemic lupus erythematosus thrombogenesis vascular endothel- ial cell damage lupus anticoagulant anticardiolipin antibody
