摘要
本文总结41例中枢神经系统白血病。此病发生率分别为急性淋巴细胞白血病26.6%急性非淋巴细胞白血病5.6%、慢性白血病0.6%。神经系统症状依白血病细胞数和入侵部位不同而异,重者可致死亡,轻者可无自觉症状。诊断应强调脑脊液内白细胞数及形态学检查。治疗一般鞘内注射氨甲喋呤5次,90%脑脊液可恢复正常,但复发者不少;理想方法是改变血-脑屏障,使化疗药物易于进入深层脑组织。
Forty one cases of central nervous system leukemia were summarized.Among themthe incidence of acute lym phoblastic leukemia was 26.6% and acute nonlymphoblasticleukemia 5.6%,and chronic leukemia 0.6%.Neurologic symptoms depened on whiteblood cells counts in the cerebro-spinal fluid and the location of leukemic infiltrate.The serious cases could be fatal;while the mild ones could have no symptoms.Fordiagnosis,the white blood cell counts and morphological examinations in cerebro-spinal fluid were emphasized.In treating these patients generally intrathecal MTXwas given 5 times,the leukemic cells in the cerebro-spinal fluid of 90% of caseswas clear,but relapse frequently occurred.The ideal method was to try to changethe blood-brain barrier so that chemotherapeutants could be easily permeated todeeper brain tissue.
出处
《天津医药》
CAS
1989年第11期657-659,共3页
Tianjin Medical Journal
