摘要
对５５例喉良性及恶性病变组织进行了Ａｇ－ＮＯＲｓ染色。结果表明喉癌组癌细胞内Ａｇ－ＮＯＲｓ颗粒形态、大小不等，散布于细胞核内，均值为３．２９±０．６３；非典型增生组上皮细胞内Ａｇ－ＮＯＲｓ颗粒大小不同，部分散在于核内，均值为２．１１±０．３４； 喉乳头状瘤细胞Ａｇ－ＮＯＲｓ颗粒大小均匀，多数位于核仁内，均值为１．７２±０．１７。经统计学处理，３组间均有显著差异（均Ｐ＜０．０１），提示Ａｇ－ＮＯＲｓ计数对喉良、恶性肿瘤的鉴别，检测癌前病变及观察肿瘤生物学行为均有意义。
Silver-binding nucleolar organizer regions (Ag-NORs)have been counted in section of routinely processed paraffinembedded tissue blocks.We have examined 55 benign and malignant lesions of larynx by this method.The Ag-NOR counts were 3.29±0.63(n=32)for carcinomas,2.11±0. 34(n=8)for atypical hyperplasia and 1.72 ±0.17(n=14) for papilloma.Carcinomas had significantly higher counts than the other two groups (P<0.01).Between atypical hyperplasia and papilloma groups,the difference of mean Ag-NOR numbers were significant(P<0.01).It may be that the numbers of Ag-NOR reflect cell biological activity or even neoplasia. This method could perhaps be used quantitatively or semiquantitatively to assist in the diagnosis of malignant and benign lesions of larynx or even precancerosis.
关键词
鳞状上皮癌
AGNOR染色
病理
喉肿瘤
squamous cell carcinoma of larynx
nucleolar organizer regions
pathology
