摘要
分别对处于麻醉（用戊巴比妥钠）和兴奋（用咖啡因）状态下的小鼠进行急性重复缺氧实验，发现两者第１次缺氧的耐受时间平均约为４２和９ｍｉｎ，分别显著长于和短于对照动物第１次缺氧的平均耐受时间（１３ｍｉｎ）。麻醉与兴奋小鼠第２、３、４次重复缺氧的耐受时间均分别约为其各自第１次缺氧耐受时间的１．６、１．８和２倍，均显著低于对照小鼠３、５、７倍的递增幅度。结果提示，麻醉和兴奋分别增强和降低动物对单次缺氧的耐受性，但对重复缺氧的耐受或适应均明显降低。
Repeated exposure to acute hypoxia was performed on pentobarbital-anesthetized and coffeine-excited mice. The average tolerance time for first run in these two groups was 42 and 9 min, which was significantly longer and shorter than that of control group(13 min) respectively.The tolerance time of second, third and forth run in anesthetized and excited mice was 1.6 , 1. 8 and 2 times longer than that of their own first run respectively. However, The results of both groups were all significantly shorter than that of control group which were 3, 5 and 7 times.These results indicate that the animal's anaesthesic and excited states may increase and decrease tolerance of the animals to first run of hypoxia respectively. However,the tolerance or adaptation to subsequent repeated hypoxia is markedly decreased in both groups.
关键词
缺氧耐受性
戊巴比妥钠
咖啡因
tolerance to acute repeated hypoxia
sodium pentobarbital
coffeine
mice
