摘要
本文报告了克山病与HLA-A、-B、-C、抗原相关研究。检测了克山病患者39例(潜在型21例,慢型18例),并检测北方之汉族无血缘关系健康人103例作为正常对照。发现HLA-Cw4相对危险率较高,RR=9.444,x^2值为17.116,P<0.001,用Fisher确切P值(1.0229×10^(-4))及校正P值处理仍有显著性差别,说明克山病与HLA-Cw4有一定的关联。
This paper reports a study on the relation between HLA and Keshan disease. Thirty-nine patients with Keshan disease (latent 21; chronic 18) and 103 control subjects of the Han nationality without blood relationship residing in Shanxi were examined.
HLA typing was done by the standard lymphocyte microcytotoxicity technique using 39 HLA-A,B,C specificities. It was found in the group of patients with Keshan disease the HLA-Cw4 frequency was higher than in the controls. The relative risk was Fisher's P value was The difference between these2 groups was significant. The results in this study indicate a relation between HLA-Cw4 and Keshan disease.
出处
《地方病通报》
1989年第1期75-79,共5页
Endemic Diseases Bulletin
关键词
白细胞抗原
克山病
human leucocyte antigen—Keshan disease—relative risk
