摘要
本文采用鼠伤寒沙门氏菌诱变性试验（Ａｍｅｓ试验）．对新型长效杀螺剂－氯硝柳胺控释剂主药氯硝柳胺进行了致突变作用的研究。在最小抑菌剂量４０μｇ／Ⅲ以下０．１２５－８μｇ／Ⅲ范围内，实验证明无致突变作用。
Mutagenicity of niclosamide, chief component of controlled release formulation of niclosamide developed in our laboratory and widely applied in schistosomiasis control program in China has been determined by Ames test with 4 histidine-requiring stains of Salmonella typhimurium TA97, TA98. TA 100 and TA 102.The results showed that niclosamide had no mutagenic effect within the concentration ranged from 0. 125-8μg/plate.
出处
《实用寄生虫病杂志》
1994年第4期30-31,共2页
Journal of Practical Parasitic Diseases
