摘要
在黄体早、中、晚期应用米非司酮合并米索前列醇与单用米非司酮进行房事后避孕临床多中心比较性研究。５４１名自愿接随机序号参加本研究的健康、月经规律妇女，组Ⅰ口服米非司酮２５ｍｇ，ｑ１２ｈ共４次，第三天上午加服米索前列醇０．４ｍｇ，妊娠率为０．４％。组Ⅱ单服米非司酮２５ｍｇ，ｑ１２ｈ，共４～６次，妊娠率为３％。二者差异有显著性（Ｐ＜０．０５）。两者引起出血类型和时间均与正常月经相似，且无明显副反应发生，错过了服用传统房事后避孕药时，采用本研究的方法可不考虑性生活时间、次数。这种方法提供了一种新型有效避孕方法。
A multicentre comparative trial on postcoital treatment against pregnancy with Mifepristone plus Misoprostol and Mifepristone alone in the luteal phase (early, midle, late was conducted.)An actual pregnant rate of 0. 4%was observed for 274 cases of healthy female volunteers with regular menstrual cycles (23-36 days). who took Mifepristone 25mg per 12h for 4 times plus Misoprostol 400μg on the morning of day 3. In contrast, 267 cases received Mifepristone 25mg per 12h for4 ￣ 6 times alone, the pregnant rate of 3% was presented. The results showed a singnificant difference. (P<0. 05).Both of the patterns and duration of induced bleeding were like normal menstruation and no any apparent side effects occurred. On this study the treatment can be given in spite of number of sexual intercourses and timing, This method provides a good new technique for postcoital treatment against pregnancy.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1994年第6期439-446,共8页
Reproduction and Contraception
