摘要
我们用酶法和过碘酸－硫代巴比妥酸法对５０例正常生育力男性和１６３例四种不育病人精浆甘油－３－磷酸胆碱（ＧＰＣ）、总唾液酸（ＴＳＡ）量进行测定后发现：１．正常男性与无精症（包括分泌性和阻塞性）、少精症精子活动率低下等精浆ＧＰＣ量有显著性差异（Ｐ＜０．０１），含量分别为２．３２±０．６６、１．７２±０．４２、０．８９±０．２６、１．３２±０．４６和１．７５±０．５２ｍｍｏｌ／Ｌ；２．正常男性与精子活动率低下、阻塞性无精等精浆ＴＳＡ量有显著性差异（Ｐ＜０．０１），而与少精和分泌性无精等差异不显著（Ｐ＞０．０５），含量分别为３８８．１６±９８．４５、４６２．６３±８０．６８、２９４．５５±９５．３７、３４９．０７±１０６．２２和３５８．５１±１１９．６２ｍｇ／Ｌ。ＧＰＣ和ＴＳＡ与精子在附睾内成熟即精子受精能力的获得与维持关系密切，精浆ＧＰＣ和ＴＳＡ的变化可能与部分男性不育有关。
The concentration of glycerol-3-phosphorylcholine (GPC) and total static acid(TSA) levels are estimated in seminal plasma from 50 fertile and 163 infertile Chinese by the enzymatic and thiobarbituric acid methods. The restllts show that the contents of GPC and TSA are 2. 32±0. 66mmol/L, 388. 14±98. 45 mg/L (X±SD) in the normozoospprmic specimens (50 cases ). In the asthenospermic specimens and the azoospermic Ⅱ (ductal obstruction), the contents of GPC and TSA are significantly different (1. 75±0. 52 mmol/L, 462. 63±80. 68 mg/L, 50 cases 1 0. 89±0.26 mmol/L, 294. 55±95. 37 mg/L. 35cases, P<0. 01).There are some significant differences between the normozoospermic specimens and the oligospermic or the azoospermic I (secretory failure) specimens in GPC content (1. 32±0. 46 mmol/L, 50 cases; 1. 72±0. 42 mmol/L, 28 cases, P<0. 01 ),' but there are no significant differences in TSA content (349. 07±106. 22 mg/L,358. 51±119. 62 mg/L. P>0. 05).In the male reprodtICtive system, the GPC and static acid are synthesized and secreted by the epididymal epithelium. Their levels in seminal plasma may influcence maturation of spermatozoa in the epididymis and be involved in the secretion of epidldymal epithelium. They may be some important indicators of the epididymal function and it suggests that different levels of GPC and TSA in seminal plasms be associated with the male infertility.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1994年第4期302-305,共4页
Reproduction and Contraception
关键词
唾液酸
精浆
不育症
男性
Glycerol-3-phosphorylcholine, Total static acid, Seminal plasma,Male infertility
