摘要
本文通过对高脂喂养家兔狭窄、分支、主动脉弓不同流场部位的观察,对流场引起动脉粥样硬化的流体力学机制进行了探讨。观察认为:高速度梯度层流流场及流动分离流场通过不同的作用方式均可引起血管内皮损伤,从而使脂质入侵,动脉粥样硬化形成,以前种流场为严重;两种流场均可引起动脉内膜增厚,内膜增生是血管对内皮损伤的反应;主动脉弓内粥样硬化易发生于二次流活跃的部位,二次流可能是主动脉弓中形成粥样硬化的主要流体力学因素。湍流引起的动脉狭窄后扩张,从流体力学角度推测其出现与否可能与介入性治疗后血管再狭窄的发生率有关。
We've studied atherogenesis resulting from flow field by observation of arteriostenosis, arteri-obranch and aortic arch of Japanese White Rabbits fed with hyperliposis diet. The results showed: high velocity gradient laminar flow and flow -separation flow field both result in atherosclerosis. The first kind of flow field results in more serious atherosclerosis. These two kinds of flow field can damage vascular endothe-lial cells by different ways and make lipoid permeate. In aortic arch, atherosclerosis tends to occur in the position where secondary flow is active : secondary flow is the main hemodynamic factor contributing to the onset of atherosclerosis in the arch of aorta.
Post-stenotic arteriodilation by turbulent flow may affect the rate of restenosis after intervenient treatment.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
1994年第3期207-211,共5页
Journal of Biomedical Engineering
关键词
流场
动脉粥样硬化
内膜增生
Flow field Atherosclerosis Intima thickening Post-stenotic arteriodilatation
