摘要
山莨菪碱诱导ＤＰＰＧ脂质体交插结构，其脂酰链末端插到对面分子层脂酰链第五个碳原子的位置，而生物膜中普遍存在的ＤＰＰＣ不能被山莨菪碱诱导形成交插相，但ＤＰＰＧ／ＤＰＰＣ混合物则能形成交插相，即伴随ＤＰＰＧ的交插，ＤＰＰＣ分子也发生交插。当ＤＰＰＧ／ＤＰＰＣ摩尔比为２：１或１：１时，其脂酰链末端插到对面分子层第八个碳原子的位置。当ＤＰＰＧ／ＤＰＰＣ摩尔比为１：２时，就不能发生交插而呈完全的非交插状态。同时，发现当体系中钠离子浓度达到４００ｍｍｏｌ／Ｌ时，山莨菪碱就不能再诱导ＤＰＰＧ形成交插凝胶相。
Anisodamine causes interdigitation in DPPG, whose phospholipid molecules insert into the opposite lipid layer with the ends of the acyl chains near to the 5th carbons of the opposing lipid molecules, whereas anisodamine can not cause interdigitation in DPPC existed generally in membranes. But anisodamine can cause interdingitation in DPPG/DPPC mixture, that is, the DPPC phospholipid molecules can produce an interdigitated structure with the DPPG phospholipid molecules interdigitating. When the proportion of DPPG/DPPC is 2:1 or 1: 1,the phospholipid molecules into the opposite lipid layer with the ends of the acyl chains near to the 8th carbons of the opposing lipid molecules . When the proportion of DPPG/DPPC is 1: 2, the non-interdigitated structure appears, Meannwhile, it showed that anisodamine could not induce acyl chain interdigitated gel phase in DPPG liposome when the sodium cation concentration was 40mmol/L in buffer system.
出处
《生物物理学报》
CAS
CSCD
北大核心
1994年第4期585-590,共6页
Acta Biophysica Sinica
基金
国家自然科学基金
