摘要
中期孕鼠在他莫昔芬作用下，其颌下腺，血清中ＥＧＦ含量下降，胎盘中ＥＧＦ受体结合位点数下降以及它的ｍＲＮＡ表达受到抑制，再次证实了他莫昔芬抑制雌激素诱导ＥＧＦ受体ｍＲＮＡ的表达。从而使ＥＧＦ受体结合位点数减少，因此，他莫昔芬对孕鼠胚胎生长发育有不可忽视的影响。
Treatment of rats during mid-term pregnancy with tamoxifen(50μg/animal/day)has decreased the concentration of epidermal growth factor (EGF) in submandibular gland and serum, and also binding activity and mRNA levels of EGF receptor in placenta. These results showed that tamoxifen significantly inhibited the estrogen-induced increase of binding activity and mRNA levels of EGF receptor in rat placenta during pregnancy. Therefore the effect of tamoxifen on the feto-placental development should not be neglected.
