摘要
根据核酸的基本特性和最新研究成果，提出了一种新的假说──反义ＲＮＡ网络：生物体内存在着许许多多小分子的基因组反义ＲＮＡ以及与之互补的反反义ＲＮＡ片段，由于机体的自身修饰作用（或其它机理），它们彼此不发生复性或杂交。这种反义ＲＮＡ网络一方面参与调控特定基因在特定部位、特定时间的启动和关闭，维持机体各种功能活动的相对稳定，另一方面对体内突变核酸和体外侵入核酸发挥特异性识别和排斥作用。
n the basis of the nature of nucleic acids andrecent research achievements or findings aboutthe macromolecuies, such as DNA-replication-repressor RNA, transcription-factor RNA,extracellular 'communicator RNA ', ri-bozyme, gene shears, RNA editing, anti-virusand anti-tumor activities of antisense RNA, anew hypothesis, antisense RNA network, isadvanced. i. e. There are many kinds of smallantisense RNAs and their complementary anti-antisense RNAs from genomic DNA within theorganism. Because of self-modification (orother mechanism), the antisense RNAs andthe anti-antisense RNAs base-pair. but do notreanneal or hybridize with each other. This an-tisense RNA network, on the one hand. par-ticipates in regulating the expression of ceriaingenes in particular tissues at particular time.keeps relative balance of various functional ac-tivities. On the other hand, the network playsan important role in specifically recognizingand eliminating the nucleic acids mutated with-in the body or invaded into the body from theoutside .
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1994年第2期178-181,共4页
Progress In Biochemistry and Biophysics
