摘要
介绍ｐ５３和Ｒｂ基因甲基比研究的最新进展。ＣｐＧ序列是ＤＮＡ甲基化和基因突变的频发位点。ｐ５３和Ｒｂ基因的ＣｐＧ序列易发生甲基化。其高度甲基化可能与基因功能失活有关，从而丧失抑制细胞增殖的功能，可能为肿瘤等发生的重要原因之一。
rogress in p53 and retinoblastoma (Rb) genemethylation is introduced. CPG dinucleotidesare the hot spots of DNA methylation and mu-tation. CpG dinucleotides of p53 and Rb geneare easily methylated. Hypermethylation ofthe tumor-suppressor genes. with consequentgene inactivation and the loss of the suppres-sion of the cellular proliferation. has been pos-tulated as one of the potential mechanism foroncogenesls.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
1994年第1期48-50,共3页
Progress In Biochemistry and Biophysics
关键词
抗癌基因
DNA
甲基化
肿瘤
tumor-suppressor gene.retinoblastoma. p53. methylation of DNA
