摘要
本文观察了中药大黄醇提物对糖尿病大鼠肾小球内多肽长生因子的影响。结果表明，糖尿病初期虽还未见肾重量的明显增加，但肾小球内生长用于的表达已显著“上调”，以链脲菌素注射后２４ｈ最明显，大黄治疗后，其多肽生长因子表达显著“下调”，并且在治疗９６ｈ后肾脏重量亦明显低于非治疗组。因此，说明大黄抑制糖尿病大鼠肾脏肥大的作用与其“下调”肾小球内多肽生长因子的表达有关。
e
studied the glomerular mRNA levelsenceding for propre EGF, PDGF-b chain , andTGF in SD rats
12, 24, 48 and 96 hours afterinjection of Streptozotocin. At 24 houre mRNAlevels measured by
dot hybridization for propreEGF,PDGF-b chain, and TGFβ1 increased 2. 8-fold (P< 0. 05) , 3.
1-fold(P<0.01) ,and 7.3-fold (P<0. 01 ) , respectively ; at 48 hours mRNAlevels for these growth
factors peaked in theglomeruli of diabetic rats as compared withcontrol rats. RO treatment
partially amelioratedthe increase of mRNA levels for propre EGF,PDGF-b chain and TGFβ in
the glomeruli ofdiabetic rats. Renal hypertrophy was obeerved at72 hours in the diabetic rats
,but not in the RO-treated rats. We concluded the abnormalproduction of growth factors in the
glomeruliwas involved in the early renal hypertrophy indiabetic mellitus and the effects of RO
on thesuppression of the renal enlarrgement in diabeticrats may be related to its effect of
down-regulated sene expression of growth factors inthe glomeruli.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1994年第4期255-258,共4页
Chinese Journal of Nephrology,Dialysis & Transplantation
