摘要
本文观察了２７例维持性血液透析患者血浆ＰＧｓ的变化。结果显示：尿毒症组血浆ＴＸＢ２、６－Ｋｅｔｏ－ＰＧＦ１α水平降低，而ＴＸＢ２／６－Ｋｅｔｏ－ＰＧＦ１α比值升高。其中有高血压者ＴＸＢ２／６－ＫｅｔｏＰＦＦ１α比值高于无高血压者。透析间期体重增加３．０ｋｇ以上者与增加不到３．０ｋｇ者相比较，ＴＸＢ２／６－Ｋｅｔｏ－ＰＧＦ１α比值无显著性差异。血透、血滤前后分别比较，ＴＸＢ２／６－Ｋｅｔｏ－ＰＧＦ１α比值透析后低于透析前。血压与血浆ＴＸＢ３比值呈正相关，与６．Ｋｅｔｏ－ＰＧＦ１α呈负相关。结果表明，维持性血液透析患者高血压与ＴＸＡ２－ＰＧＩ２平衡失调有关。血透及血滤均能降低ＴＸＢ２／６－Ｋｅｔｏ－ＰＧＦ１α比值，使高血压减轻。
The changes of plasma PGs in twenty-seven patients treated by chonic hemodia-lysis was observed,The results showed that TXB2 and 6-keto-PGFla were decreasedwhile the ratio of TXB2/-Keto-PGFla was increased,espeeially in patients with hy-pertension. There was no sighificant difference in the ratio of TXB2/6-Keto-PGPlabetween group A(△w>3.0kg)and group B(△P<3.0kg).The ratio of TXB2/6-keto-PGFIα after proceeding was lower than that before proceeding in hemodialysis or hemo-filtration, positive correlation was present between blood pressure and the ratioof TXB2/6-keto-PGFlα in plasma and negative correlation between blood pressure andplasma level of 6-Keto-PGFlα. These results suggest that hypertension is in i.relation toTXA2 PGIα imbalance,hemodialysis and hemofiltration might reduce the ratio ofTXB2-keto-PGF1α and attenuate hypertension.
出处
《上海医学》
CAS
CSCD
北大核心
1994年第11期642-645,共4页
Shanghai Medical Journal
