摘要
本文运用间接免疫荧光染色流式细胞仪分析技术检测了２８例多发性骨髓瘤患者及２０名正常对照组外周血的ＣＤ＋５６细胞。我们发现，Ⅰ期及Ⅱ期多发性骨髓瘤患者ＣＤ＋５６细胞百分率与正常人相比无明显别差（Ｐ＞０．０５），Ⅲ期患者ＣＤ＋５６细胞较正常对照组有所减少（Ｐ＜０．０５）。本文结果指出，多发性骨髓瘤早期，自然杀伤细胞在数量上无明显变化。随着病情进展，Ⅲ期患者自然杀伤细胞有关功能受到明显损害。
In the present study,we detected the CD+56 cells in peripheral blood of 28 patientswith multiple myeloma(MM)and 20 normal controls by indirect immunofluorescentstaining and flow cytometric t h iques.It was discovered that the percentage of CD+56cells in patients at stage I and stage II was hot different from that in normal controls(P>0.05),while the percentage of CD+56 cells in patients at stage III was lower thanthat in normal controls (P<0.05).Our results indicate that the natural killercells in MM at early stage have no significant change in quantity.With the diseasegoing on,the patients,immune function associated with natural killer cells would beimpaired.
出处
《上海医学》
CAS
CSCD
北大核心
1994年第4期205-206,共2页
Shanghai Medical Journal
