摘要
采用改良的八木氏插管法在３２个离体灌流的鳖心上，重点研究了对３种肾上腺素能受体激动剂的变时性反应．其亲和力顺序：ＩＳＯ＞Ｅ≥ＮＥ．ＮＥ（３．３３×１０－８ｇ）的正变时性作用可被ＰＲＯ（３．３３×１０－６ｇ）所阻断，ＰＨＥＮＴ（３．３３×１０－６ｇ）则无效．同浓度（３．３３×１０－８ｇ）的Ｅ与ＮＥ正变时性作用相近，明显强于ＳＡＬ．选择性α－受体激动剂ＭＥＴＨＯ无明显作用或略抑制．夏季与冬季的鳖心反应基本相同．提示鳖心的肾上腺素能受体主要为β－亚型而无α－受体．
The chronotropic response to the adrenergic agonists ISO,E,NE was mainly testedin 32 isolated perfused turtle Trionyx sinensis hearts. The order of affinity: ISO > E >NE. PRO (3.33×10--'g)inhibited the positive chronotropic effect of NE(3. 33×10-8g)while PHENT(3. 33×10-6g)was ineffective. With the same concentration(3. 33×10-'g),tht responses of E and NE were similar and much more effective than that ofSAL. The selective Q--agonist METHO had no obvious effect or only had slightinhibition. The responses of the turtle hearts in summer and winter were the same. Theresult indicated that the adrenergic receptors of the turtle hearts are mainly β1-subtype.
出处
《山东大学学报（自然科学版）》
CSCD
1994年第2期203-209,共7页
Journal of Shandong University(Natural Science Edition)
关键词
中华鳖
心
肾上腺素
受体
soft-shelled turtle heart
adrenergic receptor
chronotropic response
