摘要
对４７例脑血栓形成患者的血小板、凝血、抗凝和纤溶功能的变化进行了研究。结果是脑血栓形成患者血小板对ＡＤＰ和胶原的聚集反应升高，抗凝血酶Ⅲ抗原、α２巨球蛋白和蛋白Ｃ抗原显著升高，纤溶酶原活性和纤溶抑制活性显著升高，纤维蛋白原显著缩短，白陶土部分凝血活酶时间缩短，患者血液呈高凝状态。
Functions of platelet, coagulation, anticoagulation and fibrinolysis were studied in 47 patients with cerebral thrombosis. Laboratory parameters included platelet aggregation, antithrombin Ⅲ activity and its antigen, α2-macroglobulin, protein C antigen, protein S antigen, plasminogen activity, fibrinolytic activation activity, fibrinolytic inhibition activity,fibrinogen, prothrombin time and kaolin partial thromboplastin time. The results revealed that as compared to controls in Patients with cerebral thrombosis: (1) platelet aggregation induced by ADP and collagen was significantly elevated; (2) levels of antithrombin Ⅲ antigen, α2-macroglobulin and protein C antigen were markedly increased; (3) plasminogen activity and fibrinolytic inhibition activity were remarkably raised; (4) fibrinogen was significantly increased and kaolin partial throm boplastin time was shortened.Those changes suggested a hypercoagulable state developed in patients with cerebral thrombosis and their pathological implications were discussed.
出处
《山东医科大学学报》
1994年第1期58-61,共4页
Acta Academiae Medicinae Shandong
基金
山东省科委资助
关键词
血小板
血液凝固试验
脑血栓形成
Cerebral emtolism and thrombosis
Blood platelet
Blood coagulation tests
Fibrinolysis
Alpha macroglobulins
