摘要
应用非同位素细胞毒试验方法，观察了肿瘤坏死因子α（ＴＮＦα）对淋巴因子激活的杀伤细胞（ＬＡＫ）介导的子宫颈癌上皮ＳｉＨａ细胞毒作用的影响。结果表明，ＴＮＦα可增强ＬＡＫ细胞对ＳｉＨａ的杀伤作用，其作用强度与ＴＮＦα的浓度有关；ＴＮＦα预处理靶细胞使ＳｉＨａ对ＬＡＫ的敏感性无明显增强（Ｐ＞０．０５）；当ＴＮＦα对ＬＡＫ及靶细胞二者都进行预处理时的细胞毒作用显著升高（Ｐ＜０．０１）。
The effecr of tumor necrosis factor α(TNFα) on SiHa derived from cervical carcinoma in lymphokine-activated killer(LAK)cells mediated cytotoxicity was observed by a nonisotopic cytotoxicity assay. The results showed that TNFα increased the lysis to SiHa when LAK cells were pretreated with TNFα, which was TNFα dose-dependent. Pretreatment of target cells with TNFα did not effectively improve the killing mediated by LAK (P>0.05). However, it did get better killing in cases where both LAK and SiHa were pretreated by TNFα(P<0.01).
出处
《青岛医学院学报》
1994年第3期185-188,共4页
Acta Academiae Medicinae Qingdao Universitatis
