摘要
应用乳酸脱氢酶释放试验检测在Ｐ物质（ＳＰ）、５－羟色胺（５－ＨＴ）、β－内啡肽（β－ＥＰ）和甲硫脑啡肽（ＭＥＫ）几种生物活性物质体外孵育条件下，自然杀伤细胞（ＮＫ）对人食道癌上皮细胞（Ｅｃａ－１０９）的毒性作用。结果表明，几种活性物质对ＮＫ细胞毒性具有双向调整作用，对基础活性一般或偏低者具有提高作用；对基础活性偏高者具有降低作用；其提高和降低的均值具有显著性（Ｐ＜０．０５）。提示这几种活性物质在神经免疫调节过程中具有重要作用。
We studied the effects of some bioactive substances,including β-endophin(β-EN,Metenkephalin(MEK), Substance P.(SP) and 5-Hydroxytryptamine(5-HT),on the rat's natural killer(NK) cytotoxicity by the LDH assay. The results showed that the above substances could regulate the NK cytotoxicity and played a biphasic regulatory role(at a certain threshold). Their mean values of increase of decrease were significant (P<0. 05).
出处
《青岛医学院学报》
1994年第1期27-29,共3页
Acta Academiae Medicinae Qingdao Universitatis
