摘要
将70例快速诱导气管内插管的全麻病人,随机分为7组,每组10例。一组只注琥珀胆碱作对照组,其余6组分别采用不同剂量的右旋筒箭毒和本可松,以不同方式与琥珀胆碱伍用,应用序列4次测试(TOF)观察对阻滞作用的影响,以及对琥珀胆碱不良反应的预防等。并测定了诱导前后血K^+,Ca^(++)浓度进行对比。结果表明:先箭毒化对琥胆碱肌松作用无影响,能有效防止琥珀胆碱引起的束颤及血K^+增高,其差异高度显著(P<0. 01)。效应大小和阻滞性质改变随伍用非去极化肌松药的剂量不同而异,呈正性相关。阻滞性质则由去极化转为非去极化,但无迟发性呼吸抑制现象。因此,快速诱导气管内插管时先箭毒化可有效防止琥珀胆碱的不良反应,不影响肌松效果。
The effect of pretreatment with nondepolarizing muscle relaxants on response to the administration of succinylcholine was studied. Seventy patients were randomly divided into seven groups, with one group as the control, and the other six as the experimental groups to be pretreated with different doses of d-tubocu-rarine or pancuronium. After precurarization, action of succinylcholine was determined in terms of the onset, duration and attenuation of neuromuscular blockade.The severity of fasciculation and the smoothness of intubating maneuver were recorded.Serum potassium and calcium levels were also measured.The results indicated that d-tubocurarine or pancuronium prevented readily the adverse reactions induced by succinylcholine and varied with the dosage gvien in a positive relativity.The response after precurarization was found better when injections were given separately.Interactions between depolarizing and nondepolarizing relaxants were also discussed.
出处
《白求恩医科大学学报》
CSCD
1989年第6期579-583,共5页
Journal of Norman Bethune University of Medical Science
关键词
肌松药
琥珀胆碱
阻滞作用
Crash inductioa Fasciculation Precurarization Dual blockade Tachyphylaxis
