摘要
采用离体豚鼠右心空乳头肌标本灌流法，测定ＥＸ，ＰＲＯＰ，ＩＳＯ，ＮＰＥＰ四种药物引起的累积量一效曲线，ＩＳＯ，ＮＰＥＰ对乳头肌的收缩作用呈浓度依赖性增强，ｐＤ２值分别为７２６和５７８．ＥＸ对乳头肌的作用呈抑制作用，ＩＣ５０为３．１６×１０－６ｍｏｌ／Ｌ，由等效法求得ＰＲＯＰ拮抗ＩＳＯ反应的ｐＡ２值为７．８６，ＥＸ对ＩＳＯ的量一效曲线影响无显著性，ＢＸ拮抗ＮＰＥＰ反应的ｐＤ２值为５．３９．结果提示ＥＸ对心肌的抑制作用可能不通过β一受体系统。
cumulative concentration response curves of ephedroxane
(ES),prop-ranolo (PROP),iso renaline (ISO)and d-norpseudoephedrme (NPEP)were obtainedfrom
the isolated gumea-right ventricalar papillary muscles.The contraction Effets of the papillary
muscles in creased depending on concentrations of ISO and NPEP. The pD2values for ISO and
Npep are 7.26 and 5.78.Inhibitory effects were causea in the papillary muscles by EX. The
value of IC50 for EX18 3.16×10-6mol/L. The pA2 value for PROPagainst ISO is 7.86. The
metmod of Arunlakshana and schild was used to calculate the pA2value. It if not signtficant for
EX against ISO. The pD'2 value for EXagainst NPEP pA25.39. These results suggest that
inhibitory,effects of EX in ventricular muscles seem to be not exered by bera-adrenoceptor
systems.
出处
《内蒙古医学院学报》
1994年第1期23-26,共4页
Acta Academiae Medicinae Neimongol
关键词
伪麻恶唑烷
药理学
心室
乳头肌
soprenaline
d-norpseudoephedrime
propranolo
ephedroxane
papillary
