摘要
本文研究各种浓度（１０－８ｍｏｌ／Ｌ～１０－５ｍｏｌ／Ｌ）去甲肾上腺素（ＮＥ）对Ｔ淋巴细胞增殖的影响，并初步探讨ＮＥ影响Ｔ细胞功能的作用时间。实验结果说明：１０－８～１０－５ｍｏｌ／Ｌ范围内各种浓度的ＮＥ均可抑制Ｔ细胞对刀豆素Ａ（ＣｏｎＡ）的增殖反应；淋巴细胞先与ＮＥ作用１ｈ后再接受ＣｏｎＡ刺激，其增殖反应同样可被ＮＥ所抑制，但淋巴细胞接受ＣｏｎＡ刺激６ｈ后再与ＮＥ作用，其增殖反应就不再被ＮＥ所抑制，本实验结果提示，ＮＥ在较广的浓度范围内均可抑制细胞免疫功能；ＮＥ的这种免疫抑制作用可能发生于Ｔ细胞激活前或激活后初期。
The present experiments studied the influence of a range of norepinephrine(NE) concentrations on the proliferation of T lymphocyte of rat,and investigated the effective time of NE affecting the function of T lymphocyte,NE concentration of 10-8to 10-5mol/L cause inhibition of proliferation of T lymphocyte to concanavalin A(Con A).The proliferalion of T lymphocyte were still inhibited if the rat spleen cells were exposed to NE for an hour before adding Con A.However,suppressing the proliferation of T lymphocyte of NE did not occur when NE was added to spleen cell suspensions after T lymphocytes were stimulated for 6 hours by Con A.These results suggest a wide range of NE concentration can suppress cellular immunity and the immunomodulation or NE occurs before T lymphocytes were activated or early after activated.
出处
《南通医学院学报》
1994年第3期278-280,共3页
ACTA Academiae Medicinae Nantong
关键词
去甲肾上腺素
细胞免疫
T细胞
norepinephrine
T lymphocyte
neurotransmitter
cellular immunity
neuroimmunomodulation
