摘要
对３４例单纯性肾病儿童（肾病期１８例、缓解期１６例）和１４例正常儿童，分别用组织胺和ＣｏｎＡ诱导抑制性Ｔ细胞活性。结果表明，肾病期患儿组织胺诱导抑制性Ｔ细胞活性（ＨＡ－ＳＣＡ）明显高于对照组（Ｐ＜０．０５），经激素治疗后恢复正常；肾病期ＣｏｎＡ诱导抑制性Ｔ细胞活性（ＣｏｎＡ－ＳＣＡ）明显低于对照组（Ｐ＜０．０１）；ＨＡ－ＳＣＡ与血浆ＩｇＧ呈显著负相关（γ＝－０．７９，Ｐ＜０．００１）。分析结果提示，不同刺激原通过不同途径诱导出不同的抑制性细胞活性。组织胺通过免疫细胞表面的组织胺受体发挥负性调节作用，诱导出Ｔｓ。因而ＨＡ－ＳＣＡ可反映单纯性儿童肾病综合征Ｔｓ功能状态。
In the present investigation we compared 18 simple nephrotic syndromechildren and 16 remission cases with 14 matched healthy controls to determine their ability to generate suppressor cells activated by histamine and ConA in vitro. Histamine-induced suppressor cell activity(HA-SCA)was increased in nephrotic period(P<0. 05)and became normal in remission after treated with glucocorticoids. (P>0. 05). Whereas, ConA-induced suppressor cell activity was decreased in nephrotic period (P<0. 01). HA-SCA was correlated to serum IgG negatively(r=-0. 79, P<0. 001). Therefore, we suggest that histamineinduced suppressor cell activity may reflect the suppressor function in simple nephrotic syndrome.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
1994年第4期583-585,共3页
Journal of Nanjing Medical University(Natural Sciences)
关键词
肾病综合征
T细胞活性
儿童
simple nephrotic syndrome
histamine-induced suppressor cell
activity (HA-SCA)
ConA-induced suppressor cell activety (ConA-SCA)
children
