摘要
ＧＭ－ＣＳＰ本身并不能诱导人外周血单核细胞（ＰＢＭＣ）产生ＴＮＰ－α对ＬＰＳ的刺激作用也不具有协同性，但与ＩＦＮ－ｒ联合刺激ＰＢＭＣ可以产生ＴＮＦ－α，最大效应出现于刺激后１８～２４ｈ，且呈明显的时间和剂量依赖关系，消炎痛和多粘菌素Ｂ对此效应无影响，排除了ＰＧＥ２和ＬＢＳ存在影响的可能性。
n this study,the
effect of GM-CSF on TNF-α activlty induced on human monocyte was investigated.The results
demonstrated that GM-CSF alone did not stimulate TNF-α preduction,but wIth IFN-r。not with LPS,
consis-tently activated the human monocyte fOr TNF-α activity, Maximal effect occured 18 to 24
hours after stimulation, Theeffect was in a time and concentration-dependent manner and was not
influenced by indomethacin and polymyxin B。
出处
《免疫学杂志》
CAS
CSCD
北大核心
1994年第2期109-112,共4页
Immunological Journal
