摘要
本文用ＩＦＮｒ诱导人肿瘤细胞株表达ＨＬＡ－Ⅱ类抗原，并观察ＴＮＦα、ＢＣＧ－ＰＳＮ对ＩＦＮｒ诱导ＨＬＡ－Ⅱ类抗原表达的影响。发现两株肿瘤细胞当ＩＦＮｒ为５００ｕ／ｍｌ时，诱导第４天ＨＬＡ－Ⅱ类抗原表达最高；单用ＴＮＰα或ＢＣＧ－ＰＳＮ不能诱导ＨＬＡ－Ⅱ抗原表达；当ＴＮＦα、ＢＣＧ－ＰＳＮ分别与ＴＮｒ合用时，能诱导肿瘤细胞ＨＬＡ－Ⅱ类抗原的高表达率，有助于增加肿瘤细胞的免疫原性。提高宿主免疫应答能力。
it was tested that effects of tumor necrosis faator-α(TNFα) and
Bacillus-Calmatte-Guerin-Polysaccha-ride Nucleic Acid Fraction(BCG-PSN) on HLA-class Ⅱ
antigen expression in human tumor cell lines induced by inter-feron-r.The results showed that
TNFα or BCG-PSN could not induce HLA-class Ⅱ antigen synthesis and expres-sion. TNFα or
BCG-PSN might enhance the synthesis and expression of HLA-class Ⅱ antigen in tumor cells
indced byintorferon-r ,which may increase the immunapenicity of tumor cells and is a
prereiluisite for tumor-speific immune re-sponses and tumor rejection in immunocompotent
hosts.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1994年第2期105-108,112,共5页
Immunological Journal
关键词
肿瘤细胞株
干扰素
肿瘤坏死因子
Tumor call lines ,HLA-ctasa Ⅱ antigen . Interferon-r ,Tumor narosis factor-
α.BCG-PSN
